We decided to use 29" bike wheels as there is a good selection of heavy duty (tandem bike rated) components available. Unfortunately, we didn't feel like a standard width hub would give us the side loading strength we needed. Bikes lean for turning and thus other than asymmetric pedal forces, they don't get a lot of lateral loading. Narrow hubs work fine in that application, but our vehicle doesn't lean when it turns. Additionally, we need to transmit force to our axle whereas a bike hub rotates in its axle. The solution was to pick up racing kart wheels and modify them to create a hub that suits all of our needs.
We started by facing off the front and back of the kart wheels so there would be a flat area for the spoke holes.
With the wheel clamped to the index fixture, spoke holes were drilled every 20 degrees around the rim.
Here's a comparison with the original.